Mitochondrial dynamics in health and disease

In animals, mitochondria are mainly organised into an interconnected tubular network extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as well distribution tracks, counterbalancing mechanisms acting in concert to maintain mitochondrial tuned cellular function. Balanced dynamics permits quality control of including biogenesis turnover, DNA, is linked metabolic status. Cellular organismal health relies on delicate balance between large rearrangements can be seen response insults disease. Indeed, dysfunction major components fusion machineries dynamin-related protein 1 (DRP1), mitofusins 2 (MFN1, MFN2) optic atrophy (OPA1) ensuing imbalance lead neurodegenerative Altered also more common diseases. this review, machinery involved their disease will discussed.